Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signalling.

Hailou Zhang Yan Sun Suk-Yu Yau Yanmeng Zhou Xinxin Song Han-Ting Zhang Boran Zhu Haoxin Wu Gang Chen

Published in: British journal of pharmacology (2022)

Geniposide and shanzhiside methyl ester co-treatment had a synergistic rapid onset antidepressant action by triggering hippocampal PACAP activity and associated CaMKII-BDNF signalling. This mechanism could be targeted for development of fast onset antidepressants.

Keyphrases

major depressive disorder
cancer therapy
bipolar disorder
loop mediated isothermal amplification
cerebral ischemia
drug delivery
combination therapy
replacement therapy
subarachnoid hemorrhage