Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes.
Anna Sofia TrigosAnupama PasamPatricia BanksRoslyn WallaceChristina GuoSimon Paul KeamHeather Thornenull nullCatherine MitchellStephen LadeDavid CloustonAlexander HakanssonYang LiuBenjamin BlythDeclan MurphyNathan LawrentschukDamien BoltonDaniel MoonPhil DarcyYgal HauptScott G WilliamsElena CastroDavid OlmosDavid GoodePaul Joseph NeesonShahneen SandhuPublished in: Journal for immunotherapy of cancer (2022)
HRD-mutated tumors have a distinct immune microenvironment compared with sporadic tumors. Spatial profiling of T-cells provides additional information beyond T-cell density and is associated with time to biochemical recurrence, time to metastasis, tumor size and Gleason scores.