β3AR-Dependent BDNF (Brain-Derived Neurotrophic Factor) Generation Limits Chronic Postischemic Heart Failure.

Alessandro CannavoSeungho JunGiuseppe RengoFederica MarzanoJacopo AgrimiDaniela LiccardoAndrea EliaGizem KeceliGiovanna G AltobelliLorenzo Marcucci Aram MegighianErhe GaoNing Feng Kai Kammers Nicola Ferrara Livio Finos Walter J Koch Nazareno Paolocci

Published in: Circulation research (2023)

BDNF loss underscores chronic postischemic heart failure. TrkB agonists can improve ischemic LV dysfunction via replenished myocardial BDNF content. Direct cardiac β3AR stimulation, or β-blockers (via upregulated β3AR), is another BDNF-based means to fend off chronic postischemic heart failure.

Keyphrases

heart failure
left ventricular
stress induced
cardiac resynchronization therapy
acute heart failure
blood brain barrier
angiotensin converting enzyme