The Clinician's Interview-Based Impression of Change (Plus caregiver input) and goal attainment in two dementia drug trials: Clinical meaningfulness and the initial treatment response.
Justin StanleySusan E HowlettTaylor DunnKenneth RockwoodPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
The initial response to treatment, as assessed by CIBIC-Plus, remained stable for most outcome measures. Even small CIBIC-Plus improvement changes are associated with clinically meaningful change as assessed by GAS. Other tests detect decline better than improvement.