The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1.
Claire S WhyteMegan SimpsonGael B MorrowCarol A WallaceAlexander J MentzerJulian C KnightSusan ShapiroNicola S CurryCatherine N BagotHenry WatsonJamie Gray CooperNicola J MutchPublished in: Journal of thrombosis and haemostasis : JTH (2022)
This study shows that the suboptimal fibrinolytic response in COVID-19 disease is directly attributable to elevated levels of PAI-1, which attenuate plasmin generation. These data highlight the important prognostic potential of PAI-1 and the possibility of using pre-existing drugs, such as tenecteplase, to treat COVID-19 disease and potentially other respiratory diseases.