Long-term efficacy and safety of dichlorphenamide for treatment of primary periodic paralysis.

Valeria A SansoneNicholas E JohnsonMichael G HannaEmma CiafaloniJeffrey M Statland Perry B ShiehFredric CohenRobert C Griggs

Published in: Muscle & nerve (2021)

One-year open-label DCP treatment after a 9-week randomized, controlled study confirmed long-term DCP remains safe and effective for chronic use. Tolerability issues (paresthesia, cognition-related AEs) were manageable in most patients.

Keyphrases

open label
end stage renal disease
double blind
placebo controlled
clinical trial
phase iii
newly diagnosed
phase ii
chronic kidney disease
ejection fraction
peritoneal dialysis
study protocol
white matter
radiation therapy
replacement therapy