Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness.
Yu JiangDantian ZhuWenfeng LiuQiushi QinZhi FangZezheng PanPublished in: Stem cell research & therapy (2019)
We observed that the inhibition of the Hh signaling pathway with GANT61 could reduce primordial follicle number and decrease FGSC reproductive capacity or stemness through oxidative damage and apoptosis.