Neutrophils-to-Lymphocyte Ratio Is Associated with Progression and Overall Survival in Amyotrophic Lateral Sclerosis.
Maurizio Angelo LeoneJessica MandrioliSergio RussoAliona CucoviciGiulia GianferrariVitalie LisnicDafin Fior MuresanuFrancesco GiulianiMassimiliano Copettinull The Pooled Resource Open-Access Als Clinical Trials ConsortiumAndrea FontanaPublished in: Biomedicines (2022)
NLR could be a candidate easy, fast, and low-cost marker of disease progression and survival in ALS. It may be associated with low-grade inflammation either as a direct mirror of the pathological process of disease progression, or as a consequence of neuronal death (reverse causation). However, prospective studies are needed to understand whether NLR changes during the course of the disease, before using it to monitor disease progression in ALS.