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What Glues the Glue to the Cell Surface?

Aretha Fiebig
Published in: Journal of bacteriology (2022)
In the <i>Caulobacterales</i>, a highly adhesive polysaccharide called the holdfast mediates attachment to exogenous surfaces. The mechanism by which this polysaccharide is anchored to the cell envelope is not well defined. N. K. Chepkwony, G. G. Hardy, and Y. V. Brun (J Bacteriol 204:e00273-22, 2022, https://doi.org/10.1128/jb.00273-22) report the characterization of HfaE, a localized surface protein with amyloid-like properties that is required for robust holdfast anchoring. This study expands our understanding of the protein factors that attach a bacterial "superglue" to the surface of the cell.
Keyphrases
  • cell surface
  • single cell
  • cell therapy
  • amino acid
  • stem cells
  • bone marrow
  • cystic fibrosis