Beta-adrenergic signaling and T-lymphocyte-produced catecholamines are necessary for interleukin 17A synthesis.

Tatlock H Lauten Safwan K Elkhatib Tamara Natour Emily C ReedCaroline N JojoAdam J Case

Published in: bioRxiv : the preprint server for biology (2024)

Our data depict a novel role for β1/2 adrenergic receptors and autologous catecholamine signaling during T-lymphocyte IL-17A production. These findings provide a new target for pharmacological therapy in both psychiatric and autoimmune diseases associated with IL-17A-related pathology.

Keyphrases

peripheral blood
mental health
bone marrow
electronic health record
cell therapy
big data
stem cells
machine learning
artificial intelligence
data analysis
drug induced
smoking cessation