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Beta-adrenergic signaling and T-lymphocyte-produced catecholamines are necessary for interleukin 17A synthesis.

Tatlock H LautenSafwan K ElkhatibTamara NatourEmily C ReedCaroline N JojoAdam J Case
Published in: bioRxiv : the preprint server for biology (2024)
Our data depict a novel role for β1/2 adrenergic receptors and autologous catecholamine signaling during T-lymphocyte IL-17A production. These findings provide a new target for pharmacological therapy in both psychiatric and autoimmune diseases associated with IL-17A-related pathology.
Keyphrases
  • peripheral blood
  • mental health
  • bone marrow
  • electronic health record
  • cell therapy
  • big data
  • stem cells
  • machine learning
  • artificial intelligence
  • data analysis
  • drug induced
  • smoking cessation