Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models.
Sarah Louise ChristensenRikke H RasmussenSanne La CourCharlotte ErnstsenThomas F HansenLisette J A KogelmanSabrina P LauritzenGintare GuzaiteBjarne StyrishaveChristian JanfeltQadeer AzizAndrew TinkerInger Jansen-OlesenJes OlesenDavid M KristensenPublished in: Cephalalgia : an international journal of headache (2021)
Hypersensitivity provoked by GTN and levcromakalim in mice is dependent on functional smooth muscle KATP channels of extracerebral origin. These results suggest a vascular contribution to hypersensitivity induced by migraine triggers.