Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models.

Sarah Louise Christensen Rikke H RasmussenSanne La CourCharlotte ErnstsenThomas F HansenLisette J A KogelmanSabrina P LauritzenGintare GuzaiteBjarne StyrishaveChristian JanfeltQadeer AzizAndrew TinkerInger Jansen-OlesenJes OlesenDavid M Kristensen

Published in: Cephalalgia : an international journal of headache (2021)

Hypersensitivity provoked by GTN and levcromakalim in mice is dependent on functional smooth muscle KATP channels of extracerebral origin. These results suggest a vascular contribution to hypersensitivity induced by migraine triggers.

Keyphrases

smooth muscle
drug induced

mouse model
type diabetes

metabolic syndrome
adipose tissue

insulin resistance