Opposite Effect of Thyroid Hormones on Oxidative Stress and on Mitochondrial Respiration in COVID-19 Patients.
Claudia De VitisCarlo CapalboAlessandra TorselloChristian NapoliValentina SalvatiChiara LoffredoGiovanni BlandinoGiulia PiaggioFrancesca Romana AucielloFlaminia PellicciaGerardo SalernoMaurizio SimmacoLaura Di MagnoGianluca CanettieriFlaminia ColuzziRita ManciniMonica RoccoSalvatore SciacchitanoPublished in: Antioxidants (Basel, Switzerland) (2022)
Our results regarding the reduction in the serum levels of the reactive oxygen species (ROS) of COVID-19 patients with NTIS support the hypothesis that NTIS could represent an adaptative response to severe COVID-19. However, beside this beneficial effect, we demonstrate that, in the presence of an acute reduction of FT3 serum levels, the mitochondrial respiration is greatly impaired, with a consequent establishment of a hypoenergetic state of the immune cells that may hamper their capacity to react to massive viral infection.