Droplet digital PCR for sensitive relapse detection in acute myeloid leukaemia patients transplanted by reduced intensity conditioning.
Jonas Kassow GronlundChristopher VeigaardCaroline Juhl-ChristensenAnne-Sofie SkouDorte MelsvikHans Beier OmmenPublished in: European journal of haematology (2024)
These results confirm that qPCR targeting NPM1 mutations or fusion transcripts are superior in MRD testing. In the absence of such targets, ddPCR is a promising alternative demonstrating (a) high applicability, (b) high sensitivity, and (c) zero false positive MRD relapses in non-relapsing patients.
Keyphrases
- end stage renal disease
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- immune response
- liver failure
- high throughput
- rheumatoid arthritis
- systemic lupus erythematosus
- dendritic cells
- patient reported outcomes
- respiratory failure
- acute respiratory distress syndrome
- quantum dots
- extracorporeal membrane oxygenation
- real time pcr
- aortic dissection
- mechanical ventilation