Stratified Genetic Analysis Reveals Sex Differences In MPO-ANCA-associated Vasculitis.

Diana EkmanBengt SennbladAnn KnightÅsa KarlssonSolbritt Rantapää-DahlqvistEwa BerglinBernd StegmayrBo BaslundØyvind PalmHilde HaukelandIva GunnarssonAnnette BruchfeldMårten SegelmarkSophie OhlssonAladdin J MohammadAnna SvärdRille PulleritsHans HerlitzAnnika SöderberghRoald OmdalRoland JonssonLars RönnblomPer ErikssonKerstin Lindblad-TohJohanna Dahlqvist

Published in: Rheumatology (Oxford, England) (2023)

Females and males with MPO-ANCA positive AAV differ in genetic predisposition to disease, suggesting at least partially distinct disease mechanisms between the sexes. Double ANCA-positive AAV cases are genetically similar to PR3-ANCA positive cases, providing clues to the clinical follow-up and treatment of these patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
gene therapy
peritoneal dialysis
gene expression
prognostic factors
genome wide
combination therapy
patient reported outcomes