Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

Wouter VankrunkelsvenSteven ThiessenSarah DerdeEllen VervoortInge DereseIsabel PintelonHanne MatheussenAlexander JansChloë GoossensLies LangoucheGreet Van den BergheIlse Vanhorebeek

Published in: Skeletal muscle (2023)

Endogenous FGF21 is not required for sepsis survival, but may partially protect muscle force and may reduce cellular stress in muscle. Exogenous FGF21 supplementation failed to improve muscle force or cellular stress, not supporting the clinical applicability of FGF21 supplementation to protect against muscle weakness during critical illness.

Keyphrases

skeletal muscle
mouse model
intensive care unit
acute kidney injury
single molecule
heat stress
septic shock