Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction.
Elena Amaro-PrellezoMarta Gómez-FerrerLusine HakobyanImelda Ontoria-OviedoEsteban Peiró-MolinaSonia TarazonaPedro SalgueroAmparo Ruiz-SauríMarta Selva-RoldánRosa Vives-SanchezPilar SepúlvedaPublished in: Inflammation and regeneration (2024)
EVs derived from DP-MSCs exhibited similar characteristics at the omics level irrespective of the biopsy from which they were derived. All MSC-EVs exerted effective pro-resolving responses in a rat model of AMI, indicating their potential as therapeutic agents for the treatment of inflammation associated with AMI.
Keyphrases
- mesenchymal stem cells
- acute myocardial infarction
- oxidative stress
- umbilical cord
- left ventricular
- liver failure
- drug induced
- adipose tissue
- bone marrow
- respiratory failure
- ultrasound guided
- cell therapy
- anti inflammatory
- combination therapy
- risk assessment
- coronary artery disease
- human health
- hepatitis b virus
- intensive care unit
- fine needle aspiration