Modeling Diagnostic Strategies to Manage Toxic Adverse Events following Cancer Immunotherapy.
Frederik van DelftMirte MullerRom LangerakHendrik KoffijbergValesca RetèlDaan van den BroekMaarten J IJzermanPublished in: Medical decision making : an international journal of the Society for Medical Decision Making (2021)
We have obtained interesting insights by simulating a care pathway and disease progression using UPPAAL. The scenario analysis indicates that an increase in test specificity results in decreased discontinuation of treatment due to suspicion of irAEs, through a reduction of false-positive test outcomes.