Sudden Arrhythmic Death During Exercise: A Post-Mortem Genetic Analysis.

Òscar CampuzanoOlallo Sanchez-MoleroAnna FernandezIrene Mademont-SolerMonica CollAlexandra Perez-SerraJesus MatesBernat Del OlmoFerran PicoLaia Nogue-NavarroGeorgia Sarquella-BrugadaAnna IglesiasSergi CesarEsther CarroJuan Carlos BorondoJosep BrugadaJosep CastellàJordi MedalloRamon Brugada

Published in: Sports medicine (Auckland, N.Z.) (2018)

A comprehensive analysis of sudden cardiac death-related genes in individuals who died suddenly while exercising enabled the identification of potentially causative variants. However, many genetic variants remain of indeterminate significance, thus further work is needed before clinical translation. Nonetheless, comprehensive genetic analysis of individuals who died during exercise enables the detection of potentially causative variants and helps to identify at-risk relatives.

Keyphrases

copy number
high intensity
physical activity
resistance training
genome wide
loop mediated isothermal amplification
body composition
quantum dots