Multifunctional Antibacterial Nanoplatform Bi 2 WO 6 :Nd 3+ /Yb 3+ /Er 3+ @MoS 2 with Self-Monitoring Photothermal and Photodynamic Treatment.
Minkun JinJinmeng XiangChangheng ChenZhiyu ZhangYuexin LiJingjing TangChongfeng GuoPublished in: The journal of physical chemistry letters (2023)
Synergistic therapy combining photothermal therapy and photodynamic therapy is considered to be a promising approach to treat cancer, but the precise temperature control of deep tissue remains a great challenge in achieving effective treatment. Herein, a two-dimensional Bi 2 WO 6 :Nd 3+ /Yb 3+ /Er 3+ @MoS 2 nanoplatform with photothermal and photodynamic functions was constructed, where semiconductor MoS 2 serves as both a photothermal agent and a photosensitizer. The photothermal conversion performance and the reactive oxygen species generation capacity of the nanoplatform were validated under the irradiation of 808 nm laser; meanwhile, the two sets of luminescence intensity ratios ( I Yb3+ / I Nd3+ and I Er3+ / I Nd3+ ) in the biological window region were selected as near-infrared temperature probes to monitor the heat generated during the photosynergistic process in real time. The feasibility of nanoplatform as an intratissue temperature probe and antibacterial agent was further assessed by vitro experiments, which provides an idea for designing multifunctional photosynergistic therapy nanoplatform.
Keyphrases
- photodynamic therapy
- cancer therapy
- fluorescence imaging
- drug delivery
- quantum dots
- energy transfer
- room temperature
- drug release
- reactive oxygen species
- estrogen receptor
- visible light
- stem cells
- breast cancer cells
- small molecule
- living cells
- squamous cell carcinoma
- papillary thyroid
- single molecule
- wastewater treatment
- high intensity
- gold nanoparticles
- young adults
- smoking cessation
- ionic liquid