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High glucose inhibits autophagy and promotes the proliferation and metastasis of colorectal cancer through the PI3K/AKT/mTOR pathway.

Feng LiXing WanZhigui LiLi-Ming Zhou
Published in: Cancer medicine (2024)
The most favorable dose and time for tumor cells proliferation and migration is 20 mM, 48 h. High glucose fosters CRC cell proliferation and migration while suppressing autophagy through the activation of the PI3K/AKT/mTOR pathway.
Keyphrases
  • high glucose
  • signaling pathway
  • endothelial cells
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress
  • single cell
  • stem cells
  • bone marrow