K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway.

Hyeon Joo HamYong Sun LeeJaesuk YunDong Ju SonHee Pom LeeSang-Bae HanJin Tae Hong

Published in: Journal of neuroinflammation (2020)

These results suggest that K284-6111 could improve memory dysfunction by alleviating neuroinflammation through inhibiting CHI3L1 enhancing ERK-dependent PTX3 pathway.

Keyphrases

signaling pathway
traumatic brain injury
lipopolysaccharide induced
working memory
cell proliferation
pi k akt
lps induced
cognitive impairment
cerebral ischemia
oxidative stress
type diabetes
mouse model
inflammatory response
metabolic syndrome
blood brain barrier
subarachnoid hemorrhage
brain injury