Clusterin Neutralizes the Inflammatory and Cytotoxic Properties of Extracellular Histones.
Jean François AugustoCéline BeauvillainCaroline PoliLéa PaoliniIsabelle TournierPascale PignonSimon BlanchardLaurence PreisserRaffaella SoletiChloé DelépineMarine MonnierIsabelle DouchetPierre AsfarFrançois M BeloncleOlivier GuissetRenaud PrévelAlain MercatEmeline VinatierJulien GoretJean-François SubraDominique CouezMark R WilsonPatrick BlancoPascale JeanninYves DelnestePublished in: American journal of respiratory and critical care medicine (2023)
This study identifies CLU as a central endogenous histone-neutralizing molecule and suggests that, in pathologies with extensive cell death, CLU supplementation may improve disease tolerance and host survival.