Targeting NPM1 inhibits proliferation and promotes apoptosis of hepatic progenitor cells via suppression of mTOR signalling pathway.

Ping WangMin WangLin LiuHongyi LiHelin LiuJiangbo RenTianhui LiuMin CongZhijun ZhuXinyan ZhaoLiying SunJidong Jia

Published in: Stem cell research & therapy (2024)

Targeting NPM1 inhibits proliferation and induces apoptosis in hepatic progenitor cells and BEL-7402 cells, thus serving as a potential therapy for cHCC-CCA.

Keyphrases

cell cycle arrest
acute myeloid leukemia
induced apoptosis
endoplasmic reticulum stress
cell death
cancer therapy
oxidative stress
pi k akt
cell proliferation
signaling pathway
drug delivery
human health
risk assessment
climate change