Circulating Metabolomic Analysis following Cecal Ligation and Puncture in Young and Aged Mice Reveals Age-Associated Temporal Shifts in Nicotinamide and Histidine/Histamine Metabolic Pathways.
Anthony CyrLauryn KohutLauran ChambersSladjana StratimirovicBrian S ZuckerbraunPublished in: Oxidative medicine and cellular longevity (2021)
The application of untargeted plasma metabolomics identified key pathways underpinning metabolomic responses to CLP in both young and aged animals. Ultimately, these data provide a robust foundation for future mechanistic studies that may assist in improving outcomes in frail patients in response to acute stressors such as infection, trauma, or surgery.
Keyphrases
- end stage renal disease
- mass spectrometry
- ejection fraction
- minimally invasive
- chronic kidney disease
- newly diagnosed
- liver failure
- middle aged
- prognostic factors
- type diabetes
- peritoneal dialysis
- coronary artery bypass
- electronic health record
- big data
- adipose tissue
- coronary artery disease
- percutaneous coronary intervention
- intensive care unit
- hepatitis b virus
- atrial fibrillation
- machine learning
- liquid chromatography
- acute coronary syndrome
- extracorporeal membrane oxygenation
- ultrasound guided
- data analysis
- deep learning
- case control
- gas chromatography