Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia.

Xueyu QiXueli YuLong WeiHan JiangJiangwen DongHongxing LiYingying WeiLiansheng ZhaoWei DengWanjun GuoXun HuTao Li

Published in: CNS neuroscience & therapeutics (2024)

We conclude that LT-102 ameliorates cognitive impairments in a phencyclidine-induced model of schizophrenia by enhancing synaptic function, which could make it a potential therapeutic candidate for CIAS.

Keyphrases

bipolar disorder
cognitive impairment
high glucose
diabetic rats
mouse model
drug induced
oxidative stress
prefrontal cortex
stress induced