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Physicochemical stability of pevonedistat at 50, 100 and 200 µg/mL diluted in 0.9% sodium chloride and at 10 mg/mL in partially used vials.

Ralitsa DonchevaElise D'HuartNathalie SobalakJean VigneronBéatrice Demoré
Published in: European journal of hospital pharmacy : science and practice (2024)
All diluted solutions remained physically and chemically stable for 14 days, the concentrated solution did so for 7 days. No interactions between the polyolefin bag and pevonedistat were demonstrated. This new data allows re-using the concentrated solution of pevonedistat in a commercial glass vial with a Spike, and storing a preparation in case of non-administration.
Keyphrases
  • electronic health record
  • solid state
  • molecularly imprinted
  • mass spectrometry
  • high resolution