Spinal cord stimulation may improve gait and cognition in hereditary spastic paraplegia with mental retardation: a case report.
Tommaso TufoMarco CiavarroDaniela Di GiudaChiara PiccininniCarla PianoAntonio DanielePublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
In our patient, HF-SCS might have induced an activation of ascending neural pathways, resulting in changes in activity in various cortical areas (including sensory-motor cortical areas), which may give rise to a modulation of activity in spared descending motor pathways and in neural networks involved in cognitive functions, including language. Although further studies in patients with HPS are needed to clarify whether HF-SCS can be a suitable treatment option in HSP, our observation suggests that HF-SCS, a minimally invasive neurosurgical procedure, might induce beneficial effects of on various symptoms of such orphan disease.
Keyphrases
- minimally invasive
- neural network
- spinal cord
- neuropathic pain
- acute heart failure
- cerebral palsy
- spinal cord injury
- mental health
- case report
- heart failure
- mild cognitive impairment
- drug induced
- multiple sclerosis
- white matter
- robot assisted
- physical activity
- oxidative stress
- sleep quality
- pulmonary arterial hypertension
- stress induced