Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs.

Published in: Pharmaceutical research (2023)

In vitro measurement of free drug concentration in plasma under-estimates the free drug in brain in vivo if PMU in vivo from either the albumin and/or the AGP pools in plasma takes place at the BBB surface.

Keyphrases

resting state
white matter
blood brain barrier
functional connectivity
emergency department
multiple sclerosis
protein protein