Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells.
Mari Luminosa MulerFernanda AntunesGabriel Cicolin GuaracheRafaela Brito OliveiraRodrigo Portes UreshinoClaudia BincolettoGustavo José da Silva PereiraSoraya Soubhi SmailiPublished in: Einstein (Sao Paulo, Brazil) (2020)
The effect of ICI 182,780 on increasing acidic vesicular organelles in estrogen receptor-positive breast cancer cells appears to be associated with its inhibitory effect on estrogen receptors, and GPER does notseem to be involved. Understanding these mechanisms may guide further investigations of these receptors' involvement in cellular processes of breast cancer resistance.