Reduced susceptibility to aztreonam-avibactam conferred by acquired AmpC-type β-lactamases in PBP3-modified Escherichia coli.

Nicolas HelsensMustafa SadekChristophe Le TerrierLaurent PoirelPatrice Nordmann

Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2024)

Although none of the recombinant strains tested displayed clinical resistance to aztreonam-avibactam, our data emphasize that the occurrence of such profile might be of clinical relevance for MBL-producing strains.

Keyphrases

escherichia coli
klebsiella pneumoniae
gram negative
risk assessment
biofilm formation
electronic health record
big data
cell free
machine learning
pseudomonas aeruginosa
cystic fibrosis