Production and in vivo PET/CT imaging of the theranostic pair 132/135La.
Eduardo Aluicio-SarduyReinier HernandezAeli P OlsonTodd E BarnhartWeibo CaiPaul A EllisonJohnathan W EnglePublished in: Scientific reports (2019)
The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added 132/135La3+ from bulk natBa. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced 132/135La3+ has a radiochemical and radionuclidic purity amenable for 132La/135La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting 132La and ex vivo biodistribution data separately corroborated the accumulation of unchelated 132/135La3+ ions in bone and the liver.
Keyphrases
- pet ct
- positron emission tomography
- liquid chromatography
- mass spectrometry
- quantum dots
- electronic health record
- high resolution
- bone mineral density
- young adults
- magnetic resonance
- magnetic resonance imaging
- ms ms
- optical coherence tomography
- high performance liquid chromatography
- soft tissue
- diffusion weighted imaging
- tandem mass spectrometry
- gene therapy
- squamous cell
- light emitting