Association between a single nucleotide polymorphism in the R3HCC1 gene and irinotecan toxicity.

Kou KanesadaRyouichi TsunedomiShoichi HazamaHiroyuki OgiharaYoshihiko HamamotoYoshitaro ShindoHiroto Matsui MatsuiYukio TokumitsuShin YoshidaMichihisa IidaNobuaki SuzukiShigeru TakedaTatsuya IokaHiroaki Nagano

Published in: Cancer medicine (2022)

Thus, an SNP in the R3HCC1 gene may be a useful biomarker for the toxicity of irinotecan-containing chemotherapy for mCRC and pancreatic cancer.

Keyphrases

genome wide
copy number
oxidative stress
genome wide identification
dna methylation
squamous cell carcinoma
locally advanced
transcription factor
genetic diversity
chemotherapy induced