Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.

Zhe SunZiheng ZhangQiao-Qi WangJi-Long Liu

Published in: Cancer research (2022)

Inhibition of CTPS in MYC-overexpressing cells blocks pyrimidine synthesis while maintaining ribosome synthesis activity to create an anabolic imbalance that induces replication stress, providing a new approach to selectively target MYC-driven cancer. See related commentary by Chabanon and Postel-Vinay, p. 969.

Keyphrases

transcription factor
induced apoptosis
papillary thyroid
cell cycle arrest
squamous cell
endoplasmic reticulum stress
dna damage response
squamous cell carcinoma
dna damage
cell death
stress induced
pi k akt
childhood cancer
dna repair