Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection.
Nicholas J SteersYifu LiZahida DraceJustin A D'AddarioClara FischmanLili LiuKatherine XuYoung-Ji NaY Dana NeugutJun Y ZhangRoel SterkenOlivia BalderesDrew BradburyNilgun OzturkFatih OzaySanya GoswamiKarla MehlJaclyn WoldFatima Z JelloulMersedeh RohanizadeganChristopher E GilliesElena-Rodica M VasilescuGeorge VladYi-An KoSumit MohanJai RadhakrishnanDavid J CohenLloyd E RatnerFrancesco ScolariKatalin SusztakMatthew G SampsonSilvia DeaglioYasar CaliskanJonathan BaraschAisling E CourtneyAlexander P MaxwellAmy J McKnightIuliana Ionita-LazaStephan J L BakkerHarold SniederMartin H de BorstVivette D'AgatiAntonio AmorosoAli G GharaviKrzysztof KirylukPublished in: The New England journal of medicine (2019)
We found that the LIMS1 locus appeared to encode a minor histocompatibility antigen. Genomic collision at this locus was associated with rejection of the kidney allograft and with production of anti-LIMS1 IgG2 and IgG3. (Funded by the Columbia University Transplant Center and others.).