In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease.
Lana M ChahineThomas G BeachMichael C BrummCharles H AdlerChristopher S CoffeySherri MosovskyChelsea Caspell-GarciaGeidy E SerranoDavid G MunozCharles L WhiteJohn F CraryDanna JenningsPeggy TaylorTatiana ForoudVanessa ArnedoCatherine M KopilLindsey RileyKuldip D DaveBrit Mollenhauernull nullPublished in: Neurology (2020)
This study provides Class III evidence that total CSF α-synuclein does not accurately distinguish patients with PD from HCs, and that monoclonal antibody staining for SMG and skin total α-synuclein is specific but not sensitive for PD diagnosis.