A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells.

Shahi Imam RejaMuskan GuptaNeha GuptaVandana BhallaPuja OhriGurcharan KaurManoj Kumar

Published in: Chemical communications (Cambridge, England) (2018)

A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H2O2 in living cell lines.

Keyphrases

fluorescent probe
hydrogen peroxide
living cells
nitric oxide
high resolution
gene expression
cell death
resting state
dna damage
white matter
single molecule
oxidative stress
functional connectivity
reactive oxygen species
multiple sclerosis
structural basis