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Reconstructive Methodology in the Synthesis of 2-Aminopurine.

Artyom O NeymashEvgeny N UlomskyVictor V FedotovSemen V AminovDaniil N LyapustinEvgeny B GorbunovVladislav A IshimnikovPavel A SlepukhinVladimir L Rusinov
Published in: Molecules (Basel, Switzerland) (2023)
A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of the creation of a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and its subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics, and the structure of the intermediate compound 5 was established directly by X-ray diffraction analysis.
Keyphrases
  • dual energy
  • computed tomography
  • crystal structure