Cartilage Regeneration in Humans with Adipose Tissue-Derived Stem Cells and Adipose Stromal Vascular Fraction Cells: Updated Status.
Jaewoo PakJung Hun LeeNatalie PakYoon PakKwang Seung ParkJeong Ho JeonByeong Chul JeongSang-Hee LeePublished in: International journal of molecular sciences (2018)
Adipose tissue-derived stem cells (ASCs) in the form of stromal vascular fraction (SVF) and cultured expansion have been applied in clinical settings in some countries to treat osteoarthritis (OA) of knees, one of the most common debilitating, incurable disorders. Since the first report of successful cartilage-like tissue regeneration with autologous adipose SVF containing ASCs, there has been a gradual increase in the number of publications confirming such results. Thus far, most of the reports have been limited to treatments of OA of knees. Recently, successful applications of adipose SVF in treating OA of ankles and hips have been reported. In addition, several groups have reported modified methods of applying adipose SVF, such as combining bone marrow stimulation with adipose SVF or adding additional extracellular matrix (ECM) in treating OA. Here, we present an updated, systematic review of clinical effectiveness and safety in treating OA of knees, ankles, and one hip since 2016 using ASCs in the form of adipose SVF or in cultured expansion, along with a description and suggestion of potential biological mechanisms of cartilage regeneration.
Keyphrases
- adipose tissue
- stem cells
- extracellular matrix
- bone marrow
- insulin resistance
- knee osteoarthritis
- systematic review
- high fat diet
- cell therapy
- mesenchymal stem cells
- type diabetes
- skeletal muscle
- anterior cruciate ligament
- rheumatoid arthritis
- oxidative stress
- emergency department
- meta analyses
- signaling pathway
- climate change
- endoplasmic reticulum stress
- human health
- electronic health record