High CD4+:CD8+ ratios with herpes zoster infections in patients with multiple sclerosis on dimethyl fumarate.

Alexandra BalshiEmma SaartSarbesh PandeyaJohn DempseyUrsela BaberJacob A Sloane

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)

Patients with MS who develop HZ while on DMF have high CD4+:CD8+ ratios, suggesting an imbalance of CD4+ and CD8+ cells that may put a patient at risk for developing HZ while on DMF. This result emphasizes the need for lymphocyte subset monitoring (including CD4+:CD8+ ratios) on DMF, as well as vaccination prior to DMF initiation.

Keyphrases

induced apoptosis
mass spectrometry
multiple sclerosis
cell cycle arrest
ms ms
nk cells
peripheral blood
endoplasmic reticulum stress
cell death
pi k akt