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GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.

Gimena FernandezAgustina CabralPablo N De FrancescoMaia UriarteMirta ReynaldoDaniel CastrogiovanniGuillermina ZubiríaAndrés GiovambattistaSonia CantelSeverine DenoyelleJean-Alain FehrentzVirginie TolleHelgi B SchiöthMario Perello
Published in: Cellular and molecular life sciences : CMLS (2022)
neurons involves ghrelin-independent actions of GHSR at hypothalamic level and requires a decrease of plasma LEAP2 levels. We propose that the up-regulation of the actions of GHSR associated to the fall of plasma LEAP2 level are physiologically relevant neuroendocrine signals during a prolonged fasting.
Keyphrases
  • spinal cord
  • high glucose
  • diabetic rats
  • blood glucose
  • insulin resistance
  • type diabetes
  • human health
  • risk assessment
  • skeletal muscle
  • climate change