GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Gimena FernandezAgustina CabralPablo N De FrancescoMaia UriarteMirta ReynaldoDaniel CastrogiovanniGuillermina ZubiríaAndrés GiovambattistaSonia CantelSeverine DenoyelleJean-Alain FehrentzVirginie TolleHelgi B SchiöthMario PerelloPublished in: Cellular and molecular life sciences : CMLS (2022)
neurons involves ghrelin-independent actions of GHSR at hypothalamic level and requires a decrease of plasma LEAP2 levels. We propose that the up-regulation of the actions of GHSR associated to the fall of plasma LEAP2 level are physiologically relevant neuroendocrine signals during a prolonged fasting.