Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients.
Niklas BruseAnna MotosRombout van AmstelEckart de BieEmma J KooistraAron JansenDirk van LierJason KennedyDaniel SchwarzkopfDaniel Thomas-RüddelJesus F Bermejo-MartinFerran BarbeNicolette F de KeizerMichael BauerJohannes G van der HoevenAntoni TorresChristopher SeymourLonneke van VughtPeter PickkersMatthijs KoxPublished in: Intensive care medicine (2024)
Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid treatment.