The pupil constriction to light is associated with cognitive measures in middle-aged and older adults.

Yanjun ChenScott HetzelAlex A PintoAdam J PaulsenCarla R SchubertLaura M HancockBarbara E KleinNatascha MertenKaren J Cruickshanks

Published in: Aging clinical and experimental research (2022)

In this study, we provided moderate evidence suggesting the association between PLR and neuropsychological cognitive measures. The findings suggest the potential of pupil reactivity to serve as a biomarker of brain aging and warrant further longitudinal study to assess if changes in the PLR can predict cognitive decline over time.

Keyphrases

cognitive decline
mild cognitive impairment
physical activity
high intensity
multiple sclerosis
risk assessment
human health
climate change
brain injury
functional connectivity