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External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care.

Frida S Boer-PérezVictoria Lima-RogelAna Ruth Mejía-ElizondoSusanna Edith Medellín-GaribayAna S Rodríguez-BáezCristian J Rodríguez-PinalRosa Del Carmen Milán SegoviaSilvia Romano Moreno
Published in: European journal of drug metabolism and pharmacokinetics (2024)
The population pharmacokinetic model developed by Cohen-Wolkowiez et al. in 2014 demonstrated superior performance in predicting the plasma concentration of piperacillin in preterm and term Mexican neonatal intensive care patients. The Bayesian approach, including two different piperacillin plasma concentrations, was clinically acceptable regarding bias and precision. Its application for model-informed precision dosing can be an option to optimize the piperacillin dosage in our population.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • chronic kidney disease
  • ejection fraction
  • peritoneal dialysis
  • preterm infants
  • prognostic factors
  • gestational age
  • low birth weight
  • preterm birth
  • patient reported outcomes