Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice.

Jie HuangShanshan WeiZhenyu PengZijun XiaoYuanying YangJiaqin LiuBikui ZhangWenqun Li

Published in: The Journal of pharmacy and pharmacology (2022)

The study here shows that DSF protects against the AKI induced by LPS at least partially via inhibiting oxidative stress and NLRP3 inflammasome activation.

Keyphrases

nlrp inflammasome
lipopolysaccharide induced
acute kidney injury
oxidative stress
inflammatory response
cardiac surgery
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
signaling pathway
adipose tissue
anti inflammatory
type diabetes
insulin resistance