Musculoskeletal Biorepository: Establishment, Sustainment, and Tips for Success.
Joseph W GalvinBrendan M PattersonMaria BozoghlianJames V NepolaZachary T ColburnPublished in: The Journal of the American Academy of Orthopaedic Surgeons (2024)
A biorepository, also referred to as a "biobank," is a collection of biologic samples that are stored for laboratory research. With the emergence of precision medicine, the importance of leveraging individual patient biomolecular signatures to improve diagnosis, prognosis, and treatment is becoming increasingly recognized. Successful development and sustainment of a biorepository provides the potential for transformative preclinical research. Establishing a biobank requires a team approach with involvement of the institutions' research laboratory team and regulatory body. Execution of research activities requires a coordinated team approach for case identification, consent process, data and specimen collection, specimen processing, and storage and archiving. The advancing fields of precision medicine and orthobiologics provide incredible opportunities for institutions to generate novel lines of inquiry in musculoskeletal diseases through a multiomics approach (genomic, transcriptomic, proteomic, microbiomic). In addition, a biobank is an important component of post-market surveillance for the rapidly emerging field of orthobiologics.
Keyphrases
- palliative care
- quality improvement
- public health
- rheumatoid arthritis
- case report
- electronic health record
- genome wide
- rna seq
- copy number
- single cell
- cell therapy
- health insurance
- machine learning
- gene expression
- mesenchymal stem cells
- stem cells
- dna methylation
- human health
- climate change
- deep learning
- data analysis
- smoking cessation