Pharmacokinetics of chloroquine and primaquine in healthy volunteers.
André DaherDouglas Pereira PintoLaís Bastos da FonsecaHeliana Martins PereiraDiego Medeiros Dias da SilvaLetícia de Sá Fernandes Vallim da SilvaAlessandra Lanzillotta EstevesJuliana J Soares MedeirosJorge Souza MendonçaPublished in: Malaria journal (2022)
In conclusion, the three studies provided detailed chloroquine and primaquine pharmacokinetic data in accordance with current regulatory standards. Together with other open data initiatives, this individual data may increase the accuracy of pharmacokinetic models guiding best dose, new combinations, regimens and formulations to optimize the current chloroquine and primaquine treatments for vivax malaria. The data presented here may support the deployment of high-quality drugs and evidence-based public health policies.