Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)-Hydroxy Norketamine.
Shafiq Ur RahmanQiang HaoKaiwu HeYumeng LiXifei YangTao YeTahir AliQiang ZhouShupeng LiPublished in: Proteomics. Clinical applications (2020)
The core protection mechanisms of HNK observed herein involves improving the abnormal ATP synthesis, impaired glycolysis, and the defense system therefore provides mechanistic insight and molecular targets for novel antidepressants.