Cancer gene expression profiles associated with clinical outcomes to chemotherapy treatments.
Nicolas M BorisovMaxim SorokinVictor TkachevAndrew GarazhaAnton BuzdinPublished in: BMC medical genomics (2020)
We collected a database of gene expression profiles associated with clinical responses on chemotherapy for 2786 individual cancer cases. Among them seven datasets included RNA sequencing data (for 645 cases) and the others - microarray expression profiles. The cases represented breast cancer, lung cancer, low-grade glioma, endothelial carcinoma, multiple myeloma, adult leukemia, pediatric leukemia and kidney tumors. Chemotherapeutics included taxanes, bortezomib, vincristine, trastuzumab, letrozole, tipifarnib, temozolomide, busulfan and cyclophosphamide.
Keyphrases
- gene expression
- low grade
- multiple myeloma
- papillary thyroid
- childhood cancer
- dna methylation
- acute myeloid leukemia
- high grade
- squamous cell
- locally advanced
- single cell
- squamous cell carcinoma
- endothelial cells
- high dose
- newly diagnosed
- type diabetes
- machine learning
- adipose tissue
- metabolic syndrome
- allogeneic hematopoietic stem cell transplantation
- tyrosine kinase
- metastatic breast cancer
- data analysis