Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer.

Liangliang CaiHua BaiJianchun DuanZhijie WangShugeng GaoDi WangShuhang WangJun JiangJiefei HanYanhua TianXue ZhangHao YeMinghui LiBingding HuangJie HeJie Wang

Published in: Journal for immunotherapy of cancer (2019)

To our knowledge, this is the first report for direct link between the methylome alterations and TMB in NSCLCs. High TMB NSCLCs had more DNAm aberrance and copy number variations (CNVs). In addition, the TMB distribution of Chinese NSCLCs population is lower than that of TCGA.

Keyphrases

copy number
mitochondrial dna
dna methylation
genome wide
healthcare
gene expression
risk factors
nk cells