Therapeutic targeting of PLK1 in TERT promoter-mutant hepatocellular carcinoma.

Qin TangGuanghui HuYe SangYulu ChenGuangyan WeiMeiyan ZhuMengke ChenShiyong LiRengyun Liu Zhen-Wei Peng

Published in: Clinical and translational medicine (2024)

TERT promoter mutation confers sensitivity to PLK1 inhibitors in HCC. The selective growth inhibition of TERT mutant HCC cells induced by PLK1 inhibitor was mediated by Smad3. Combined inhibition of PLK1 and Smad3 showed a cooperative anti-tumor effect in TERT mutant HCC cells.

Keyphrases

induced apoptosis
cell cycle arrest
dna methylation
epithelial mesenchymal transition
gene expression
wild type
transforming growth factor
transcription factor
endoplasmic reticulum stress
cell death
cell proliferation
drug delivery
pi k akt